Diarrhoea is caused by many different organisms, including bacteria, viruses and protozoan parasites. In many cases, however, an infectious agent is not always present, as in patients with inflammatory bowel disease, or as a side effect of cancer or HIV drugs. This diversity of causative agents makes diarrhoea difficult to treat, and there are no products available that can treat all causes.
Anatara’s Detach® contains the active ingredient Bromelain, which is a mixture of proteases extracted from pineapple stems. Specific proteases within Bromelain have anti-attachment, anti-secretory and anti-inflammatory activity. Collectively, these proteases contribute to the broad spectrum activity of Detach® as they not only prevent the diarrhoea-causing organism from attaching to the small intestine in the first place, but they also block inflammation and the secretory action of toxins, the underlying cause of diarrhoea. This anti-secretory mode of action means that Detach® can be used to treat, as well as prevent, diarrhoea.
Detach® should be effective against most types of diarrhoea, regardless of the cause.
How Detach® works
- Detach® stops bacteria from attaching to the small intestine, and therefore prevents diarrhoea from occurring in the first place.
- Detach® blocks the secretory pathways used by toxins and inflammatory mediators that stimulate fluid secretion.
As Detach® is not an antibiotic and does not target the pathogens themselves, it will not contribute to the growing problem of antibiotic-resistance, a serious global health problem.
Bromelains are already listed on the Australian Register of Therapeutic Goods (ARTG) and similar registers around the world, and the US Food and Drug Administration (FDA) has granted bromelain GRAS (generally recognised as safe) status for food uses. Bromelains are also approved for human use by the Therapeutic Goods Administration (TGA), the Food Standards of Australia and New Zealand (ANZFA) and The Joint FAO/WHO Expert Committee on Food Additives (JECFA), and the FDA.