Despite advancements in weight loss treatments, challenges remain. Injectable GLP-1 receptor agonists demonstrate efficacy in reducing weight, however, the high cost and invasive administration are deterrents to ready use. Importantly, rebound weight gain following discontinuation presents significant management challenges and inherent risks, and possible long term side-effects from systemic GLP-1 treatments are still being fully assessed.
Rebound weight gain has been shown to exacerbate existing health risks, including adverse cardiovascular events, metabolic instability, and emotional distress.